| 7:00 - 8:30 AM |
Breakfast: University Place Hotel, 850 West Michigan Street, Indianapolis, IN
46202 (All registrants invited to breakfast) |
| 8:30 - 9:00 AM |
Walk to Walther Hall 2nd Floor Auditorium |
| 9:00 - 10:00 AM |
SESSION 3 - Islet ß-Cell Growth (Moderator: Adolfo
Garcia-Ocaña) |
| 9:00 - 9:15 am |
DAWN BELT DAVIS - 'The role of FoxM1 in beta cell proliferation in mouse and
human pancreatic islets'. |
| 9:15 - 9:30 am |
NAGESHA GUTHALU - 'Parathyroid hormone-related protein (PTHrP) enhances human
beta cell proliferation and function with simultaneous induction of
cyclin-dependent-kinase 2 (cdk2) and CyclinE expression'. |
| 9:30 - 9:45 am |
TAYLOR ROSA - 'Hepatocyte growth factor (HGF) overexpression in the beta cell
ameliorates hyperglycemia in Irs2-deficient mice by increasing beta cell mass
and maintaining compensatory hyperinsulinemia'. |
| 9:45 - 10:00 am |
PATRICK FUEGER - 'Effects of Dexamethasone on Beta Cell Proliferation'. |
| 10:00-10:15 am |
SARA ERNST - 'The HGF/cMet Signaling Pathway is Essential for Pancreatic
Beta-Cell Regeneration'. |
|
| 10:00 - 10:30 AM |
Coffee Break |
| 10:30 - 12:00 PM |
SESSION 4 - Islet ß-Cell Death and Survival (Moderator: John
Corbett) |
| 10.45 - 11.00 am |
JEREMY LAVINE - 'Cholecystokinin is upregulated in obese islets and expands
beta-cell mass by increasing beta-cell survival'. |
| 11.00 - 11.15 am |
GORDON MEARES - 'Connecting ER stress signaling to mTOR: IRE1 dependent
activation of AMPK in response to nitric oxide'. |
| 11.15 - 11.30 am |
REIESHA ROBBINS - 'Deoxyhypusine Syn11.00 - 11.15 am |
| 11.30 - 11.45 am |
AARON BALDWIN - 'Aberrant Palmitoylation Induces ER Stress and Death in the
Beta-cell'. |
| 11.45 - 12.00 pm |
MING LIU - 'Mutant Preproinsulin Induced Diabetes'. |
|
| 12:00 - 1:30 pm |
Lunch, Medical Science Building Atrium |
| 1:30 - 2:45 PM |
SESSION 5 - Islet ß-Cell Signaling for Insulin Secretion (Moderator: Les
Satin) |
| 1:30 -1:45 pm |
LYNLEY POUND - 'Is G6PC2/IGRP a component of the beta cell glucose sensor?' |
| 1:45 - 2:00 pm |
MATTHEW MERRINS - 'Metabolic Oscillations in Islets Depend on Ca2+ Level but not
Ca2+ Oscillations'. |
| 2:00 - 2.15 pm |
RICHARD BENNINGER - 'Islet Gap Junction Coupling and the Regulation Insulin
Secretion'. |
| 2:15 - 2:30 pm |
EUNJIN OH -Munc18-1 is a key regulator of first-phase insulin secretion in human
and mouse islet beta cells and in the maintenance of whole-body glucose
homeostasis'. |
| 2:30 - 2:45 pm |
JAMIE CANTRELL - 'Analysis of the role of sphingosine-1-phosphate in pancreatic
beta-cell function'. |
|
| 2:45 - 3:30 pm |
Tea Break |
| 3:30 - 4:45 PM |
SESSION 6 - Insights into Islet Dysfunction (Moderator: Debbie
Thurmond) |
| 3:30 - 3.45 pm |
N.S. KAYTON - 'Loss of Beta Cell-Resident Epidermal Growth Factor Receptor
Impairs Glucose-Stimulated Insulin Secretion'. |
| 3:45 - 4:00 pm |
ALEJANDRO AKROUH - 'Functional Study of Compound Heterozygous Mutations in the
SUR1 Subunit of Pancreatic KATP Channels That Cause Neonatal Diabetes'. |
| 4:00 - 4:15 pm |
STACEY DULA - 'Evidence that low-grade systemic inflammation can induce
beta-cell failure'. |
| 4:15 - 4:30 pm |
SINDU RAJAN - 'SUMO mediated regulation of Glucagon Like Peptide Receptor-1
activity'. |
| 4:30 - 4:45 pm |
DEAN WISEMAN - 'Glucose-Induced S-Nitrosylation of Syntaxin 4 Regulates Insulin
Exocytosis from Pancreatic Beta Cells'. |
|
| 4:45 - 5:15 PM |
Break |
| 5:15 - 6:15 PM |
SESSION 7 - THE 3RD ANNUAL LACY MEDAL LECTURE (Moderator: CHRIS
RHODES)
BARBARA E. CORKEY Ph.D. (Boston University) - 'Mechanisms for Basal
Hypersecretion of Insulin' |
| 6:15 - 7:00 pm |
Break, Posters and Social: Medical Science Building Atrium |
| 7:00- 10:00 pm |
Dinner and Awards |
